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CCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production

Authors: Nan Liang, Ming-Dong Yao, Ying Wang, Jia Liu, Lu Feng, Zhi-Ming Wang, Xiang-Yu Li, Wen-Hai Xiao, Ying-Jin Yuan

Journal: J Agric Food Chem

PubMed ID: 34554747

Doi: 10.1021/acs.jafc.1c04588

Products & Services: Mutagenesis Services

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma

Authors: Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin, Angela L Meunier, Yifan Dang, Beth Ostaszewski, Alison C Pietras, Andrew M Stern, Dennis J Selkoe

Journal: Alzheimers Dement

PubMed ID: 34550630

Doi: 10.1002/alz.12457

Products & Services: Mutagenesis Services

Cellular retinoid-binding proteins transfer retinoids to human cytochrome P450 27C1 for desaturation

Authors: Sarah M Glass, F Peter Guengerich

Journal: J Biol Chem

PubMed ID: 34480899

Doi: 10.1016/j.jbc.2021.101142

Products & Services: Mutagenesis Services

TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth

Authors: Tsz-Yin Chan, Christina M Egbert, Julia E Maxson, Adam Siddiqui, Logan J Larsen, Kristina Kohler, Eranga Roshan Balasooriya, Katie L Pennington, Tsz-Ming Tsang, Madison Frey, Erik J Soderblom, Huimin Geng, Markus Müschen, Tetyana V Forostyan, Savannah Free, Gaelle Mercenne, Courtney J Banks, Jonard Valdoz, Clifford J Whatcott, Jason M Foulks, David J Bearss, Thomas O'Hare, David C S Huang, Kenneth A Christensen, James Moody, Steven L Warner, Jeffrey W Tyner, Joshua L Andersen

Journal: Nat Commun

PubMed ID: 34504101

Doi: 10.1038/s41467-021-25622-3

Products & Services: Mutagenesis Services

Genetic and phenotypic heterogeneity in KIAA0753-related ciliopathies

Authors: Katherine A Inskeep, Yuri A Zarate, Danielle Monteil, Jurgen Spranger, Dan Doherty, Rolf W Stottmann, K Nicole Weaver

Journal: Am J Med Genet A

PubMed ID: 34523780

Doi: 10.1002/ajmg.a.62497

Products & Services: Mutagenesis Services

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Authors: Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

Journal: J Clin Invest

PubMed ID: 34623328

Doi: 10.1172/JCI145472

Products & Services: Mutagenesis Services

Exploration of the Role of the C-Terminal Domain of Human DNA Topoisomerase IIα in Catalytic Activity

Authors: Ashley C Dougherty, Mariam G Hawaz, Kristine G Hoang, Judy Trac, Jacob M Keck, Carmen Ayes, Joseph E Deweese

Journal: ACS Omega

PubMed ID: 34660952

Doi: 10.1021/acsomega.1c02083

Products & Services: Mutagenesis Services

The DNA Recognition Motif of GapR Has an Intrinsic DNA Binding Preference towards AT-rich DNA

Authors: Qian Huang, Bo Duan, Zhi Qu, Shilong Fan, Bin Xia

Journal: Molecules

PubMed ID: 34641320

Doi: 10.3390/molecules26195776

Products & Services: Mutagenesis Services

A Secreted Chorismate Mutase from pv Attenuates Virulence and Walnut Blight Symptoms

Authors: Renata de A B Assis, Cíntia H D Sagawa, Paulo A Zaini, Houston J Saxe, Phillip A Wilmarth, Brett S Phinney, Michelle Salemi, Leandro M Moreira, Abhaya M Dandekar

Journal: Int J Mol Sci

PubMed ID: 34638715

Doi: 10.3390/ijms221910374

Products & Services: Mutagenesis Services

Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue

Authors: Juan Luis Pacheco-Garcia, Ernesto Anoz-Carbonell, Pavla Vankova, Adithi Kannan, Rogelio Palomino-Morales, Noel Mesa-Torres, Eduardo Salido, Petr Man, Milagros Medina, Athi N Naganathan, Angel L Pey

Journal: Redox Biol

PubMed ID: 34537677

Doi: 10.1016/j.redox.2021.102112

Products & Services: Mutagenesis Services