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Improved EGFR mutation detection sensitivity after enrichment by Cas9/sgRNA digestion and PCR amplification

Authors: Li Wang, Jing Jiang, Xiangning Li, Kai Li, Rongzhang He, Jia Li, Lili Duan, Weihao Luo, Zheng Hu, Dixian Luo

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 33216845

Doi: 10.1093/abbs/gmaa123

Products & Services: Mutagenesis Services Gene Synthesis

PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability

Authors: Noélia Che, Kai-Yu Ng, Tin-Lok Wong, Man Tong, Phillis Wf Kau, Lok-Hei Chan, Terence K Lee, Michael Sy Huen, Jing-Ping Yun, Stephanie Ma

Journal: Cancer Lett

PubMed ID: 33186656

Doi: 10.1016/j.canlet.2020.11.002

Products & Services: Mutagenesis Services

A Global Map of G Protein Signaling Regulation by RGS Proteins

Authors: Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA

Journal: Cell

PubMed ID: 33007266

Doi: 10.1016/j.cell.2020.08.052

Products & Services: Mutagenesis Services

Neurogenetic fetal akinesia and arthrogryposis: genetics, expanding genotype-phenotypes and functional genomics

Authors: Ravenscroft G, Clayton JS, Faiz F, Sivadorai P, Milnes D, Cincotta R, Moon P, Kamien B, Edwards M, Delatycki M, Lamont PJ, Chan SH, Colley A, Ma A, Collins F, Hennington L, Zhao T, McGillivray G, Ghedia S, Chao K, O'Donnell-Luria A, Laing NG, Davis MR

Journal: Journal of medical genetics

PubMed ID: 33060286

Doi: 10.1136/jmedgenet-2020-106901

Products & Services: Mutagenesis Services

Ligand with Two Modes of Interaction with the Dopamine D₂ Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism

Authors: Ågren R, Zeberg H, Stępniewski TM, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K

Journal: ACS Chemical Neuroscience

PubMed ID: 32865974

Doi: 10.1021/acschemneuro.0c00477

Products & Services: Mutagenesis Services

The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells

Authors: Sheng-Li Ming, Lei Zeng, Yu-Kun Guo, Shuang Zhang, Guo-Li Li, Ying-Xian Ma, Yun-Yun Zhai, Wen-Ru Chang, Le Yang, Jiang Wang, Guo-Yu Yang, Bei-Bei Chu

Journal: Front Immunol

PubMed ID: 33072119

Doi: 10.3389/fimmu.2020.575818

Products & Services: Mutagenesis Services Plasmid DNA Preparation

The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility

Authors: Tseng KF,Mickolajczyk KJ,Feng G,Feng Q,Kwok ES,Howe J,Barbar EJ,Dawson SC,Hancock WO,Qiu W

Journal: Current biology : CB

PubMed ID: 32735815

Doi: 10.1016/j.cub.2020.06.090

Products & Services: Mutagenesis Services

Exploring the molecular determinants for subtypeselectivity of 2‑amino‑1,4,5,6‑ tetrahydropyrimidine‑5‑carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrateinhibitors

Authors: Stefanie Kickinger , Anas Al-Khawaja , Anne Stæhr Haugaard , Maria E K Lie , Francesco Bavo , Rebekka Löffler , Maria Damgaard , Gerhard F Ecker , Bente Frølund , Petrine Wellendorph

Journal: Sci Rep

PubMed ID: 32747622

Doi: 10.1038/s41598-020-69908-w

Products & Services: Mutagenesis Services

Structural Characterization of Sphingomonas sp. KT‑1 PahZ1- Catalyzed Biodegradation of Thermally Synthesized Poly(aspartic acid)

Authors: Chad A. Brambley, Austin L. Bolay, Henry Salvo, Amanda L. Jansch, Tarah J. Yared, Justin M. Miller, Jamie R. Wallen, and Mitch H. Weiland

Journal: sustainable

Doi: 10.1021/acssuschemeng.0c01158

Products & Services: Mutagenesis Services Gene Synthesis

Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation

Authors: Bhavika Nagareddy, Arafat Khan, Hyungjin Kim

Journal: J Biol Chem