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Targeted Delivery of mRNA with Polymer−Lipid Nanoparticles for In Vivo Base Editing

Authors: Qimingxing Chen, Yan Chang, Xiaoyan He, Yan Ding, Runyuan Wang, Ran Luo, Jialu Yuan, Jiabei Chen, Guisheng Zhong, Huiying Yang, Jia Chen, Jianfeng Li

Journal: ACS Nano

PubMed ID: 39962883

Doi: 10.1021/acsnano.4c14041

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Fullerol Initiates Stem Cell–Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling

Authors: Haoyang Liu, Yue Zhu, Weixu Chen, Renwang Sheng, Chuanquan Liu, Yuzhi Sun, Jia Liu, Mingyue Wang, Jun Lu, Jialin Chen, Wei Zhang

Journal: ACS Applied Materials & Interfaces

Doi: 10.1021/acsami.5c01731

Products & Services: Recombinant Proteins

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Authors: Anoop S Chauhan, Matthew J W Mackintosh, Joseph Cassar, Alexander J Lanz, Mohammed Jamshad, Hannah L Mackay, Alexander J Garvin, Alexandra K Walker, Satpal S Jhujh, Teresa Carlomagno, Aneika C Leney, Grant S Stewart, Joanna R Morris

Journal: Nature Communication

PubMed ID: 40229270

Doi: 10.1038/s41467-025-56974-9

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Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian

Journal: Cell Rep

PubMed ID: 40272981

Doi: 10.1016/j.celrep.2025.115611

Products & Services: Peptide Synthesis

Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy

Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang

Journal: Advanced Functional Materials

Doi: doi.org/10.1002/adfm.202501954

Products & Services: Recombinant Proteins

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu

Journal: Cell Discov

PubMed ID: 11962085

Doi: 10.1038/s41421-025-00779-z

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Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry

Authors: Yafeng Wu，Zixuan Chen，Fengxiang Chen，Juan Su，Jianyu Han，Songqin Liu

Journal: Anal Chem

PubMed ID: 40183921

Doi: 10.1021/acs.analchem.5c00365

Products & Services: Peptide Synthesis

Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus

Authors: Haining Li , Luyuan Shao , Zhe Liu , Qi Liu , Ye Xiang