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PARP1-DNA co-condensation drives DNA repair site assembly to prevent disjunction of broken DNA ends

Authors: Nagaraja Chappidi 1, Thomas Quail 2, Simon Doll 3, Laura T Vogel 4, Radoslav Aleksandrov 5, Suren Felekyan 4, Ralf Kühnemuth 4, Stoyno Stoynov 5, Claus A M Seidel 4, Jan Brugués 6, Marcus Jahnel 3, Titus M Franzmann 1, Simon Alberti

Journal: Cell

PubMed ID: 38320550

Doi: 10.1016/j.cell.2024.01.015

Products & Services: Codon Optimization Gene Synthesis

Structure basis for recognition of plant Rpn10 by phytoplasma SAP05 in ubiquitin-independent protein degradation

Authors: Liying Zhang, Yunxiang Du, Qian Qu, Qingyun Zheng

Journal: iScience

PubMed ID: 38322988

Doi: 10.1016/j.isci.2024.108892

Products & Services: Proteins, Expression, Isolation and Analysis

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Authors: Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee

Journal: biorxiv

PubMed ID: 38328070

Doi: 10.1101/2024.01.20.575817

Products & Services: Gene Synthesis

CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression

Authors: Mengxi Huang, Panpan Zhou, Yang Hang, Dan Wu, Nan Zhao, Genhong Yao, Xiaojun Tang, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 38183912

Doi: 10.1016/j.intimp.2024.111485

Products & Services: Molecular Biology Reagents

A novel opsonic eCIRP inhibitor for lethal sepsis

Authors: Colleen P Nofi, Chuyi Tan, Gaifeng Ma, Molly Kobritz, Jose M Prince, Haichao Wang, Monowar Aziz, Ping Wang

Journal: J Leukoc Biol

PubMed ID: 37774691

Doi: 10.1093/jleuko/qiad119

Products & Services: Catalog Peptides

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

Authors: Maryamsadat Seyedsadr, Madison Bang, Ethan McCarthy, Shirley Zhang, Ho-Chung Chen, Mahnia Mohebbi, Willy Hugo, Jason K Whitmire, Melissa G Lechner, Maureen A Su

Journal: biorxiv

PubMed ID: 38260637

Doi: 10.1101/2024.01.07.574553

Products & Services: ORF cDNA Clones/MolecularCloud

Molecular mechanisms and evolutionary robustness of a color switch in proteorhodopsins

Authors: Jiafei Mao, Xinsheng Jin, Man Shi, David Heidenreich, Lynda J Brown, Richard C D Brown, Moreno Lelli, Xiao He, Clemens Glaubitz

Journal: Sci Adv

PubMed ID: 38266078

Doi: 10.1126/sciadv.adj0384

Products & Services: Custom Vector Construction

Enantioselective Toxicity and Potential Endocrine-Disruptive Effects of the Insecticides Flufiprole and Ethiprole on

Authors: Lianshan Li, Xuejun Zhao, Kunming Hu, Weiye Xu, Minghua Wang, Hongjie Wang

Journal: J Agric Food Chem

PubMed ID: 38190123

Doi: 10.1021/acs.jafc.3c07896

Products & Services: Gene Synthesis

An inoculation site-retained mRNA vaccine induces robust immune responses against SARS-CoV-2 variants

Authors: Lei Huang, Fanfan Zhao, Muye He, Yi Fang, Xiaoping Ma, Shuaiyao Lu, Entao Li, Hui Xiao, Hanfei Zhu, Xueli Wang, Siyuan Tang, Bo Yu, Jie Wang, Dong Zhao, Chao Wang, Hangwen Li, Yuwei Gao, Xiaozhong Peng, Haifa Shen

Journal: J Control Release

PubMed ID: 38184234

Doi: 10.1016/j.jconrel.2024.01.002

Products & Services: Recombinant Proteins

Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection

Authors: Guorong Sun, Kai Alexander Kropp, Marieluise Kirchner, Nina Plückebaum, Anton Selich, Manutea Serrero, Akshay Dhingra, Jorge Rubén Cabrera, Birgit Ritter, Rudolf Bauerfeind, Emanuel Wyler, Markus Landthaler, Axel Schambach, Beate Sodeik, Philipp Mertins, Abel Viejo-Borbolla

Journal: MBio

PubMed ID: 38275838

Doi: 10.1128/mbio.03308-23

Products & Services: Codon Optimization