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Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML

Authors: Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly Klega, Radoslaw P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah N Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong

Journal: Blood

PubMed ID: 38096371

Doi: 10.1182/blood.2023021105

Products & Services: Peptide Synthesis

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules

Authors: Jiaqi Hu, Juling Jiang, Bowen Xu, Yue Li, Bei Wang, Shulin He, Xiaoling Ren, Bolun Shi, Xing Zhang, Honggang Zheng, Baojin Hua, Rui Liu

Journal: J Ethnopharmacol

PubMed ID: 38113986

Doi: 10.1016/j.jep.2023.117590

Products & Services: Proteins, Expression, Isolation and Analysis

Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis

Authors: Stephen Lu, John F Andersen, Christopher F Bosio, B Joseph Hinnebusch, José M Ribeiro

Journal: Commun Biol

PubMed ID: 38110569

Doi: 10.1038/s42003-023-05679-0

Products & Services: Recombinant Proteins

Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer

Authors: Kodchakorn Mahasongkram, Kantaphon Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Monrat Chulanetra, Nitat Sookrung, Oytip Nathalang, Wanpen Chaicumpa

Journal: Vaccines (Basel)

PubMed ID: 38140230

Doi: 10.3390/vaccines11121826

Products & Services: Recombinant Proteins

Efficient de novo production of bioactive cordycepin by Aspergillus oryzae using a food-grade expression platform

Authors: Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Chanikul Chutrakul, Wanwipa Vongsangnak, Kobkul Laoteng

Journal: Microb Cell Fact

PubMed ID: 38071331

Doi: 10.1186/s12934-023-02261-5

Products & Services: Molecular Biology Reagents

Resveratrol-derived inhibitors of the E3 ubiquitin ligase PELI1 inhibit the metastasis of triple-negative breast cancer

Authors: Guangsen Xu, Qian Zhou, Jie Qi, Zhongyue Li, Lijun Yin, Zhuoran Li, Chunhua Lu, Baobing Zhao, Yuemao Shen

Journal: Eur J Med Chem

PubMed ID: 38150964

Doi: 10.1016/j.ejmech.2023.116060

Products & Services: PCR Cloning and Subcloning

Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells

Authors: Ali S Alfardan, Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Mohammed Alqinyah, Sabry M Attia, Wedad Sarawi, Ahmed Z Alanazi, Khalid Alhazzani, Khalid E Ibrahim

Journal: Int Immunopharmacol

PubMed ID: 38056199

Doi: 10.1016/j.intimp.2023.111293

Products & Services: PCR Cloning and Subcloning

Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model

Authors: Jawad Ali, Amjad Khan, Jun Sung Park, Muhammad Tahir, Waqas Ahmad, Kyonghwan Choe, Myeong Ok Kim

Journal: Nutrients

PubMed ID: 38068844

Doi: 10.3390/nu15234986

Products & Services: Peptide Synthesis

Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Authors: Ricardo Cruz-Acuña, Secunda W Kariuki, Kensuke Sugiura, Spyros Karaiskos, Eleanor M Plaster, Claudia Loebel, Gizem Efe, Tatiana Karakasheva, Joel T Gabre, Jianhua Hu, Jason A Burdick, Anil K Rustgi

Journal: J Clin Invest

PubMed ID: 37788109

Doi: 10.1172/JCI168146

Products & Services: Peptide Synthesis

An evolutionarily conserved serine protease network mediates melanization and Toll activation in

Authors: Tisheng Shan, Yang Wang, Krishna Bhattarai, Haobo Jiang

Journal: Sci Adv

PubMed ID: 38117884

Doi: 10.1126/sciadv.adk2756

Products & Services: Proteins, Expression, Isolation and Analysis