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Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.
Authors: WangYue,ZhiYanle,JinQiaomei,LuShuai,LinGuowu,YuanHaoliang,YangTaotao,WangZhanwei,YaoChao,LingJun,GuoHao,LiTonghui,JinJianlin,LiBaoquan,ZhangLi,ChenYadong,L
Journal: J. Med. Chem.
PubMed ID: 29357250
Doi: 10.1021/acs.jmedchem.7b01261
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Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.
Authors: MarksIsaac S,GardeenSpencer S,KurdzielSarah J,NicolaouSonia T,WoodsJ Evan,KularatneSumith A,LowPhil
Journal: Mol. Pharm.
PubMed ID: 29715036
Doi: 10.1021/acs.molpharmaceut.8b00139
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Milk-derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Pre-adipocytes.
Authors: ChakrabartiSubhadeep,JahandidehForough,DavidgeSandra T,WuJian
Journal: J. Agric. Food Chem.
PubMed ID: 30160110
Doi: 10.1021/acs.jafc.8b02051
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Microcarriers with synthetic hydrogel surfaces for stem cell expansion
Authors: Andrew D. Dias, Jonathan M. Elicson, and William L. Murphy
Journal: Advanced Healthcare Materials
Doi: 10.1002/adhm.201700072
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Octopamine and tyramine regulate the activity of reproductive visceral muscles in the adult female blood-feeding bug, Rhodnius prolixus
Authors: Sam Hana , Angela B. Lange
Journal: The Journal of Experimental Biology
Doi: 10.1242/jeb.156307
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Early IFNγ-Mediated and Late Perforin-Mediated Suppression of Pathogenic CD4 T Cell Responses Are Both Required for Inhibition of Demyelinating Disease by CNS-Specific Autoregulatory CD8 T Cells.
Authors: Boyden Alexander W,Brate Ashley A,Karandikar Nit
Journal: Front Immunol
PubMed ID: 30356717
Doi: 10.3389/fimmu.2018.02336
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Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.
Authors: Toledo Miriam,Batista-Gonzalez Ana,Merheb Emilio,Aoun Marie Louise,Tarabra Elena,Feng Daorong,Sarparanta Jaakko,Merlo Paola,Botrè Francesco,Schwartz Gary J,Pessin Jeffrey E,Singh R
Journal: Cell Metab.
PubMed ID: 29937374
Doi: 10.1016/j.cmet.2018.05.023
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Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D.
Authors: Qiang Z,, Zhou ZY,, Peng T,, Jiang PZ, Shi N,, Njoya EM,, Azimova B, Liu WL, Chen WH,, Zhang GL, Wang F.
Journal: J Exp Clin Cancer Res
PubMed ID: 30482227
Doi: 10.1186/s13046-018-0971-4
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TBC1D5 controls the GTPase cycle of Rab7b.
Authors: Borg Distefano M, Hofstad Haugen L, Wang Y, Perdreau-Dahl H, Kjos I, Jia D, Morth JP,, Neefjes J, Bakke O, Progida C.
Journal: J Cell Sci
PubMed ID: 30111580
Doi: 10.1242/jcs.216630
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Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope
Authors: Krishnarjuna B, Sugiki T, Morales RAV, Seow J, Fujiwara T, Wilde KL, Norton RS, MacRaild CA
Journal: Communications Biology
PubMed ID: 30271940
Doi: 10.1038/s42003-018-0063-1
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