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Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model

Authors: Julie A Zorn, Matthew L Wheeler, Ralston M Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y-C Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop

Journal: Sci Rep

PubMed ID: 35241687

Doi: 10.1038/s41598-022-06953-7

Products & Services: Plasmid DNA Preparation

Design of protein-binding proteins from the target structure alone

Authors: Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, David Baker

Journal: Nature

PubMed ID: 35332283

Doi: 10.1038/s41586-022-04654-9

Products & Services: Plasmid DNA Preparation

Biodiversity and infrastructure interact to drive tourism to and within Costa Rica

Authors: Alejandra Echeverri, Jeffrey R Smith, Dylan MacArthur-Waltz, Katherine S Lauck, Christopher B Anderson, Rafael Monge Vargas, Irene Alvarado Quesada, Spencer A Wood, Rebecca Chaplin-Kramer, Gretchen C Daily

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35245152

Doi: 10.1073/pnas.2107662119

Products & Services: Plasmid DNA Preparation

Genetic ablation of the Bsx homeodomain transcription factor in zebrafish: Impact on mature pineal gland morphology and circadian behavior

Authors: Mikkel Bloss Carstensen, Adar Medvetzky, Alon Weinberger, Wolfgang Driever, Yoav Gothilf, Martin Fredensborg Rath

Journal: J Pineal Res

PubMed ID: 35249239

Doi: 10.1111/jpi.12795

Products & Services: Plasmid DNA Preparation

Baohuoside I Inhibits Tumor Angiogenesis in Multiple Myeloma the Peroxisome Proliferator-Activated Receptor γ/Vascular Endothelial Growth Factor Signaling Pathway

Authors: Ying Chen, Lina Zhang, Xiaoyan Zang, Xuxing Shen, Jianyong Li, Lijuan Chen

Journal: Front Pharmacol

PubMed ID: 35341213

Doi: 10.3389/fphar.2022.822082

Products & Services: Plasmid DNA Preparation

Large-scale design and refinement of stable proteins using sequence-only models

Authors: Jedediah M Singer, Scott Novotney, Devin Strickland, Hugh K Haddox, Nicholas Leiby, Gabriel J Rocklin, Cameron M Chow, Anindya Roy, Asim K Bera, Francis C Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J Stewart, David Baker, Eric Klavins

Journal: PLoS ONE

PubMed ID: 35286324

Doi: 10.1371/journal.pone.0265020

Products & Services: Plasmid DNA Preparation

Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

Authors: Berto Tejera-Hernández, Danielle E Goodman, Juan M Nevarez, Katherine R Spindler

Journal: J Virol

PubMed ID: 35285681

Doi: 10.1128/jvi.02063-21

Products & Services: Plasmid DNA Preparation

Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98

Authors: Lisa Diez, Larisa E Kapinos, Janine Hochmair, Sabrina Huebschmann, Alvaro Dominguez-Baquero, Amelie Vogt, Marija Rankovic, Markus Zweckstetter, Roderick Y H Lim, Susanne Wegmann

Journal: Int J Mol Sci

PubMed ID: 35408855

Doi: 10.3390/ijms23073495

Products & Services: Plasmid DNA Preparation

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

Authors: Prashant Monian, Chikdu Shivalila, Genliang Lu, Mamoru Shimizu, David Boulay, Karley Bussow, Michael Byrne, Adam Bezigian, Arindom Chatterjee, David Chew, Jigar Desai, Frank Favaloro, Jack Godfrey, Andrew Hoss, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Amber Lindsey, Fangjun Liu, Richard Looby, Subramanian Marappan, Jake Metterville, Ronelle Murphy, Jeff Rossi, Tom Pu, Bijay Bhattarai, Stephany Standley, Snehlata Tripathi, Hailin Yang, Yuan Yin, Hui Yu, Cong Zhou, Luciano H Apponi, Pachamuthu Kandasamy, Chandra Vargeese

Journal: Nat Biotechnol

PubMed ID: 35256816

Doi: 10.1038/s41587-022-01225-1

Products & Services: Plasmid DNA Preparation

Downregulation of m A writer complex member METTL14 in bladder urothelial carcinoma suppresses tumor aggressiveness

Authors: Catarina Guimarães-Teixeira, João Lobo, Vera Miranda-Gonçalves, Daniela Barros-Silva, Cláudia Martins-Lima, Sara Monteiro-Reis, José Pedro Sequeira, Isa Carneiro, Margareta P Correia, Rui Henrique, Carmen Jerónimo

Journal: Mol Oncol

PubMed ID: 35048498

Doi: 10.1002/1878-0261.13181

Products & Services: Plasmid DNA Preparation