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Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.
Authors: XueXiaoqian,ZhangYan,LiuZhaoxuan,SongMing,XingYanli,XiangQiuping,WangZhen,TuZhengchao,ZhouYulai,DingKe,Xu
Journal: J. Med. Chem.
PubMed ID: 26731490
Doi: 10.1021/acs.jmedchem.5b01511
Products & Services: Gene Synthesis   
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Authors: ToonenLodewijk J A,SchmidtIris,LuijsterburgMartijn S,van AttikumHaico,van Roon-MomWilleke
Journal: Sci Rep
PubMed ID: 27731380
Doi: 10.1038/srep35200
Products & Services: Gene Synthesis   
Comparative Community Proteomics Demonstrates the Unexpected Importance of Actinobacterial Glycoside Hydrolase Family 12 Protein for Crystalline Cellulose Hydrolysis.
Authors: HirasJennifer,WuYu-Wei,DengKai,NicoraCarrie D,AldrichJoshua T,FreyDario,KolinkoSebastian,RobinsonErrol W,JacobsJon M,AdamsPaul D,NorthenTrent R,SimmonsBlake A,SingerStev
Journal: MBio
PubMed ID: 27555310
Doi: 10.1128/mBio.01106-16
Products & Services: Gene Synthesis   
Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.
Authors: MaesoIgnacio,DunwellThomas L,WyattChris D R,MarlétazFerdinand,VetőBorbála,BernalJuan A,QuahShan,IrimiaManuel,HollandPeter
Journal: BMC Biol.
PubMed ID: 27296695
Doi: 10.1186/s12915-016-0267-0
Products & Services: Gene Synthesis   
Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML.
Authors: HuangJu,LiuYuanfeng,AuBryan C,BarberDwayne L,ArrudaAndrea,SchambachAxel,RotheMichael,MindenMark D,PaigeChristopher J,MedinJeffr
Journal: Mol Ther Methods Clin Dev
PubMed ID: 27933304
Doi: 10.1038/mtm.2016.74
Products & Services: Gene Synthesis   
Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.
Authors: TatzelKatharina,KurokiLindsay,DmitrievIgor,KashentsevaElena,CurielDavid T,GoedegebuureS Peter,PowellMatthew A,MutchDavid G,HawkinsWilliam G,Spitzer
Journal: Sci Rep
PubMed ID: 26935795
Doi: 10.1038/srep22661
Products & Services: Gene Synthesis   
Structure-function analysis of myomaker domains required for myoblast fusion.
Authors: MillayDouglas P,GamageDilani G,QuinnMalgorzata E,MinYi-Li,MitaniYasuyuki,Bassel-DubyRhonda,OlsonEr
Journal: Proc. Natl. Acad. Sci. U.S.A.
PubMed ID: 26858401
Doi: 10.1073/pnas.1600101113
Products & Services: Gene Synthesis   
Expanding Biosensing Abilities through Computer-Aided Design of Metabolic Pathways.
Authors: LibisVincent,DelépineBaudoin,FaulonJean-
Journal: ACS Synth Biol
PubMed ID: 27028723
Doi: 10.1021/acssynbio.5b00225
Products & Services: Gene Synthesis   
Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage.
Authors: WangShan,LiuKai,XiaoLe,YangLiYuan,LiHong,ZhangFeiXue,LeiLei,LiShengQing,FengXu,LiAiYing,He
Journal: Nucleic Acids Res.
PubMed ID: 26400161
Doi: 10.1093/nar/gkv949
Products & Services: Gene Synthesis   
In Vitro Antiviral Activity and Resistance Profile Characterization of the Hepatitis C Virus NS5A Inhibitor Ledipasvir.
Authors: Cheng G, Tian Y, Doehle B, Peng B, Corsa A, Lee YJ, Gong R, Yu M, Han B, Xu S, Dvory-Sobol H, Perron M, Xu Y, Mo H, Pagratis N, Link JO, Delaney W.
Journal: Antimicrob Agents Chemother.
PubMed ID: 26824950
Products & Services: Gene Synthesis   
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