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Scanning mutagenesis of the voltage-gated sodium channel Na12 using base editing

Authors: Juan Lorenzo B Pablo, Savannah L Cornett, Lei A Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H Thompson, John G Doench, Dennis Lal, Alfred L George, Jen Q Pan

Journal: Cell Rep

PubMed ID: 38823014

Doi: 10.1016/j.celrep.2024.114327

Products & Services: Gene Synthesis

mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

Products & Services: Gene Synthesis

Novel enzymes for biodegradation of polycyclic aromatic hydrocarbons identified by metagenomics and functional analysis in short-term soil microcosm experiments

Authors: Kinga K Nagy, Kristóf Takács, Imre Németh, Bálint Varga, Vince Grolmusz, Mónika Molnár, Beáta G Vértessy

Journal: Sci Rep

PubMed ID: 38773163

Doi: 10.1038/s41598-024-61566-6

Products & Services: Gene Synthesis

Nanobody-based immunosensor for the detection of H pylori in saliva

Authors: Mohammad Ia Ahmad, Célia G Amorim, Luay F Abu Qatouseh, Maria C B S M Montenegro

Journal: Biosens Bioelectron

PubMed ID: 38810413

Doi: 10.1016/j.bios.2024.116423

Products & Services: Gene Synthesis

Early Animal Origin of BACE1 APP/Aβ Proteolytic Function

Authors: James A Langeland, Lillian Baumann, Eva M DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D Blaine Moore

Journal: Biology (Basel)

PubMed ID: 38785802

Doi: 10.3390/biology13050320

Products & Services: Gene Synthesis

Three in one: An effective and universal vaccine expressing heterologous tandem RBD trimer by rabies virus vector protects mice against SARS-CoV-2

Authors: Jingbo Huang, Weiqi Wang, Hailun Li, Yujie Bai, Yumeng Song, Cuicui Jiao, Hongli Jin, Pei Huang, Haili Zhang, Xianzhu Xia, Feihu Yan, Yuanyuan Li, Hualei Wang

Journal: Antiviral Res

PubMed ID: 38740191

Doi: 10.1016/j.antiviral.2024.105905

Products & Services: Gene Synthesis

TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

Authors: Yanting Lin, Rui Gao, Dongquan Jing, Yiming Liu, Huijuan Da, Lutz Birnbaumer, Yong Yang, Xinghua Gao, Zhenhua Gao, Qiuhua Cao

Journal: Front Pharmacol

PubMed ID: 38835669

Doi: 10.3389/fphar.2024.1392328

Products & Services: Gene Synthesis

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes

Authors: Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Zhiya Yu, Sivasish Sindiri, Jared J Gartner, Maria Parkhurst, Sri Krishna, Frank J Lowery, Nikolaos Zacharakis, Lior Levy, Todd D Prickett, Tiffany Benzine, Satyajit Ray, Robert V Masi, Billel Gasmi, Yong Li, Rafiqul Islam, Alakesh Bera, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg

Journal: J Immunother Cancer

PubMed ID: 38816232

Doi: 10.1136/jitc-2023-008645

Products & Services: Gene Synthesis

Selective activation of naïve B cells with unique epitope specificity shapes autoantibody formation in celiac disease

Authors: Saykat Das, Jorunn Stamnaes, Lene S Høydahl, Christine Skagen, Knut E A Lundin, Jørgen Jahnsen, Ludvig M Sollid, Rasmus Iversen

Journal: J Autoimmun

PubMed ID: 38754235

Doi: 10.1016/j.jaut.2024.103241

Products & Services: Gene Synthesis

Assessing the Impact of Novel Exon 11 Variants on Pre-mRNA Splicing

Authors: Halla Elshwekh, Inas M Alhudiri, Adam Elzagheid, Nabil Enattah, Yasmine Abbassi, Lubna Abou Assali, Ilenia Marino, Cristiana Stuani, Emanuele Buratti, Maurizio Romano

Journal: Cells

PubMed ID: 38786046

Doi: 10.3390/cells13100824

Products & Services: Gene Synthesis