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The MUC5B-associated variant, rs35705950, resides within an enhancer subject to lineage- and disease-dependent epigenetic remodeling

Authors: Fabienne Gally, Sarah K Sasse, Jonathan Kurche, Margaret A Gruca, Jonathan H Cardwell, Tsukasa Okamoto, Hong Wei Chu, Xiaomeng Hou, Olivier Poirion, Justin Buchanan, Sebastian Preissl, Bing Ren, Sean P Colgan, Robin D Dowell, Ivana V Yang, David A Schwartz, Anthony N Gerber

Journal: JCI Insight

PubMed ID: 33320836

Doi: 10.1172/jci.insight.144294

Products & Services: Gene Synthesis

Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs)

Authors: He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J

Journal: Journal of molecular biology

PubMed ID: 33157083

Doi: 10.1016/j.jmb.2020.10.031

Products & Services: Gene Synthesis

A highly sensitive and rapid enzymatic method using a biochemical automated analyzer to detect inorganic pyrophosphate generated by nucleic acid sequence-based amplification

Authors: Isobe A, Iwabuchi Y, Yajima M, Sakasegawa SI, Yamaguchi Y, Seimiya M, Umemura T, Osawa S

Journal: Clinica chimica acta; international journal of clinical chemistry

PubMed ID: 33096031

Doi: 10.1016/j.cca.2020.10.026

Products & Services: Gene Synthesis

Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii

Authors: Ren B, Kong P, Hedar F, Brouwers JF, Gupta N

Journal: Communications Biology

PubMed ID: 33303967

Doi: 10.1038/s42003-020-01480-5

Products & Services: Gene Synthesis

FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis

Authors: Wang C, Shen J, Ying J, Xiao D, O'Keefe RJ

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 33199631

Doi: 10.1073/pnas.2017056117

Products & Services: Gene Synthesis

High-Throughput Screening for Drugs That Inhibit Papain-Like Protease in SARS-CoV-2

Authors: Smith E, Davis-Gardner ME, Garcia-Ordonez RD, Nguyen TT, Hull M, Chen E, Baillargeon P, Scampavia L, Strutzenberg T, Griffin PR, Farzan M, Spicer TP

Journal: SLAS discovery : advancing life sciences R & D

PubMed ID: 33043784

Doi: 10.1177/2472555220963667

Products & Services: Gene Synthesis

Apremilast interferes with the TGFβ1-induced transition of human skin fibroblasts into profibrotic myofibroblasts: in vitro study

Authors: Cutolo M, Soldano S, Montagna P, Martinelli G, Tardito S, Corallo C, Giordano N, Tavilla P, Cozzani E, Parodi A, Sulli A, Pizzorni C, Patane M, Smith V, Paolino S

Journal: Rheumatology (Oxford, England)

PubMed ID: 32725130

Doi: 10.1093/rheumatology/keaa249

Products & Services: Gene Synthesis

NEase-based amplification for detection of miRNA, multiple miRNAs and circRNA

Authors: Yajun Zhang, Qiuyang Zhang, Xiaocheng Weng, Yuhao Du, Xiang Zhou

Journal: Anal Chim Acta

PubMed ID: 33453881

Doi: 10.1016/j.aca.2020.12.024

Products & Services: Gene Synthesis

Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production

Authors: Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Yoichi Sasaki, Kenji Fukumoto, Sadatsugu Sakane, Yuki Makino, Nobuyuki Takemura, Ryoko Yamada, Minoru Shigekawa, Takahiro Kodama, Ryotaro Sakamori, Shogo Kobayashi, Tomohide Tatsumi, Hiroshi Suemizu, Hidetoshi Eguchi, Norihiro Kokudo, Masashi Mizokami, Tetsuo Takehara

Journal: Gastroenterology

PubMed ID: 33346004

Doi: 10.1053/j.gastro.2020.12.015

Products & Services: Gene Synthesis

NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning.

Authors: Rathore OS,Silva RD,Ascensão-Ferreira M,Matos R,Carvalho C,Marques B,Tiago MN,Prudêncio P,Andrade RP,Roignant JY,Barbosa-Morais NL,Martinho RG

Journal: RNA (New York, N.Y.)

PubMed ID: 32963109

Doi: 10.1261/rna.077446.120

Products & Services: Gene Synthesis