miR-190a-5p expression alters dynamically in response to hypoxia. However， the role of miR-190a-5p expression in hypoxia-induced pulmonary hypertension (PH) remains unclear. We sought to correlate the miR-190a-5p expression levels with the severity， diagnosis， and prognosis of PH in relation to chronic obstructive pulmonary disease (COPD-PH). Additionally， we evaluated the effect of miR-190a-5p through in vitro experiments on human pulmonary endothelial cells (HPECs) that were exposed to hypoxia and in vivo experiments using an animal model of hypoxia-induced PH.
miR-190a-5p expression alters dynamically in response to hypoxia. However， the role of miR-190a-5p expression in hypoxia-induced pulmonary hypertension (PH) remains unclear. We sought to correlate the miR-190a-5p expression levels with the severity， diagnosis， and prognosis of PH in relation to chronic obstructive pulmonary disease (COPD-PH). Additionally， we evaluated the effect of miR-190a-5p through in vitro experiments on human pulmonary endothelial cells (HPECs) that were exposed to hypoxia and in vivo experiments using an animal model of hypoxia-induced PH.
