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Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer.

Prostate Cancer Prostatic Dis.. 2019-05; 
KrookMelanie A，BarkerHannah，ChenHui-Zi，ReeserJulie W，WingMichele R，MartinDorrelyn，SmithAmy M，DaoThuy，BonnevilleRussell，SamorodnitskyEric，MiyaJharna，FreudAharon G，MonkJ Paul，ClintonSteven K，RoychowdhurySa
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Custom Vector Construction … Cells also underwent routine short tandem repeat profiling to confirm identities. cDNA plasmid generation, lentivirus production and transduction. The KLK2-FGFR2 fusion was generated and cloned into the pLVX-IRES-Puro vector (Clontech) by GenScript (Supplementary Fig … Get A Quote

摘要

The fibroblast growth factor receptor (FGFR) signaling pathway is activated in multiple tumor types through gene amplifications， single base substitutions， or gene fusions. Multiple small molecule kinase inhibitors targeting FGFR are currently being evaluated in clinical trials for patients with FGFR chromosomal translocations. Patients with novel gene fusions involving FGFR may represent candidates for kinase inhibitors.

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