Antibodies against IgLON5， a neuronal adhesion protein of unknown function， are markers of a novel neurological disorder termed anti-IgLON5 syndrome. The disorder shows a remarkable association with the HLA-DQB1*0501 and HLA-DRB1*1001 alleles， and postmortem studies demonstrate a novel neuronal tauopathy predominantly involving the hypothalamus and tegmentum of the brainstem. The role of IgLON5 antibodies in the pathogenesis of the disease is currently unknown. Here， we have determined the target epitopes of IgLON5 antibodies， the effects of the IgLON5 antibodies in rat hippocampal neurons， and the IgG subclass responsible for these effects.
Antibodies against IgLON5， a neuronal adhesion protein of unknown function， are markers of a novel neurological disorder termed anti-IgLON5 syndrome. The disorder shows a remarkable association with the HLA-DQB1*0501 and HLA-DRB1*1001 alleles， and postmortem studies demonstrate a novel neuronal tauopathy predominantly involving the hypothalamus and tegmentum of the brainstem. The role of IgLON5 antibodies in the pathogenesis of the disease is currently unknown. Here， we have determined the target epitopes of IgLON5 antibodies， the effects of the IgLON5 antibodies in rat hippocampal neurons， and the IgG subclass responsible for these effects.
