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Mitochondrial transcription factor A， an endogenous danger signal， promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells.

PLoS ONE. 2013; 
JulianMark W，ShaoGuohong，VangundyZachary C，PapenfussTracey L，CrouserEllio
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Gene Synthesis … Editor: Patricia Fitzgerald-Bocarsly, University of Medicine and Dentistry of New Jersey - New Jersey Medical School, United States of America … fMMYALF, the N-terminal sequence of mitochondrial NADH dehydrogenase subunit 6 (ND6)] was synthesized by GenScript Corp … Get A Quote

摘要

Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We hypothesized that TFAM， bound to mtDNA (or equivalent CpG-enriched DNA)， amplifies TNFα release from TLR9-expressing plasmacytoid dendritic cells (pDCs) by engaging RAGE.

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