Thioredoxin-interacting protein (Txnip)， an inhibitor of thioredoxin (Trx)， increases in diabetic nephropathy and promotes oxidative stress. The angiotensin II (Ang II) receptor blocker telmisartan may protect renal function in diabetic models and patients via multiple effects including antioxidation. However， its mechanism has not been fully elucidated， and its relationship to Txnip remains unclear.