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Bioinformatics for the synthetic biology of natural products: integrating across the Design-Build-Test cycle.

Nat Prod Rep. 2016; 
CarbonellPablo,CurrinAndrew,JervisAdrian J,RattrayNicholas J W,SwainstonNeil,YanCunyu,TakanoEriko,BreitlingRa
Products/Services Used Details Operation
Gene Synthesis Furthermore, many commercial gene synthesis vendors (including Gen9, GeneArt and GenScript) provide their own optimization algorithms for use prior to submitting orders, which allows further specific optimization for their synthesis methodology. Get A Quote

摘要

Covering: 2000 to 2016Progress in synthetic biology is enabled by powerful bioinformatics tools allowing the integration of the design, build and test stages of the biological engineering cycle. In this review we illustrate how this integration can be achieved, with a particular focus on natural products discovery and production. Bioinformatics tools for the DESIGN and BUILD stages include tools for the selection, synthesis, assembly and optimization of parts (enzymes and regulatory elements), devices (pathways) and systems (chassis). TEST tools include those for screening, identification and quantification of metabolites for rapid prototyping. The main advantages and limitations of these tools as w... More

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