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Immunogenicity of mumps virus vaccine candidates matching circulating genotypes in the United States and China.

Vaccine. 2017; 
ZengelJames,PhanShannon I,PickarAdrian,XuPei,He
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Gene Synthesis … But, after numerous large outbreaks in the United States, the goal is to have under 500 reported cases per year [17]. However, in 2016, there were over 4000 cases in the United States [18] … The DNA for PZH0804 replacement was generated by gene synthesis (GenScript) … Get A Quote

摘要

Mumps virus (MuV) causes acute infection in humans with characteristic swelling of the parotid gland. While vaccination has greatly reduced the incidence of MuV infection, there have been multiple large outbreaks of mumps virus (MuV) in highly vaccinated populations. The most common vaccine strain, Jeryl Lynn, belongs to genotype A, which is no longer a circulating genotype. We have developed two vaccine candidates that match the circulating genotypes in the United States (genotype G) and China (genotype F). We found that there was a significant decrease in the ability of the Jeryl Lynn vaccine to produce neutralizing antibody responses to non-matched viruses, when compared to either of our vaccine ca... More

关键词

Genotype F,Genotype G,Mumps,Vac