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Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells.

Microb. Cell Fact.. 2016; 
SouzaBianca Mendes,PreisserTatiane Melo,PereiraVanessa Bastos,Zurita-TurkMeritxell,de CastroCamila Prósperi,da CunhaVanessa Pecini,de OliveiraRafael Pires,Gomes-SantosAna Cristina,de FariaAna Maria Caetano,MachadoDenise Carmona Cara,ChatelJean-Marc,AzevedoVasco Ariston de Carvalho,LangellaPhilippe,MiyoshiAnde
Products/Services Used Details Operation
Plasmid DNA Preparation The IL-4 ORF of Mus musculus was amplified using the synthetic plasmid pUC57::IL-4 (GenScript) as a template. Get A Quote

摘要

Inflammatory bowel diseases are characterized by chronic intestinal inflammation that leads to severe destruction of the intestinal mucosa. Therefore, the understanding of their aetiology as well as the development of new medicines is an important step for the treatment of such diseases. Consequently, the development of Lactococcus lactis strains capable of delivering a eukaryotic expression vector encoding the interleukin 4 (IL-4) of Mus musculus would represent a new strategy for the elaboration of a more effective alternative therapy against Crohn's disease.

关键词

Crohn’s disease,Interleukin 10,Interleukin 4,Lactococcus lactis,Regulatory c