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Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals.

BMC Biol.. 2016; 
MaesoIgnacio，DunwellThomas L，WyattChris D R，MarlétazFerdinand，VetőBorbála，BernalJuan A，QuahShan，IrimiaManuel，HollandPeter
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Gene Synthesis Human ARGFX coding sequence was synthesized by GenScript USA, DPRX and LEUTX were cloned by ligating products of exon-specific genomic PCRs and TPRX1 was generated by ligating a 5’ TPRX2 region with 100 % identity to TPRX1 with TPRX1-specific 3’-region amplified from human DNA. Get A Quote

摘要

A central goal of evolutionary biology is to link genomic change to phenotypic evolution. The origin of new transcription factors is a special case of genomic evolution since it brings opportunities for novel regulatory interactions and potentially the emergence of new biological properties.

关键词

Asymmetric evolution，Embryo，Homeodomain，PRD，Placental，Tandem duplica
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