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Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: insights from the promoter fusion studies.

Microb. Cell Fact.. 2016; 
SekurovaOlga N，ZhangJianhai，KristiansenKåre A，ZotchevSerg
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Plasmid DNA Preparation The latter plasmid was used to clone a synthetic gusA gene codon-optimized for S. venezuelae (GenScript, USA) under control of ermEp*, yielding plasmid pSOK808. Get A Quote

摘要

Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES)， respectively. Biosynthesis of Cml and Jad was shown to be reciprocally regulated via the action of regulatory proteins JadR1 and JadR2 encoded by the jad cluster， and mechanism of such regulation has been characterized. However， detailed analysis of the regulatory mechanism controlling Cml biosynthesis is still lacking.

关键词

Antibiotic biosynthesis，Environmental stress，Promoter fusions，Regulation，Streptom
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