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MicroRNA-17–92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats

Original Contribution. 2016; 
Hongqi Xin, PhD; Mark Katakowski, PhD; Fengjie Wang, MS; Jian-Yong Qian, PhD; Xian Shuang Liu, PhD; Meser M. Ali, PhD; Benjamin Buller, PhD; Zheng Gang Zhang, MD, PhD; Michael Chopp, PhD
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Gene Synthesis To generate tailored MSC exosomes containing elevated miR-17–92 cluster, an miR-17–92 cluster–contained plasmid (pCAG-GFPmiR-17–92, constructed according to our published protocol16) was transfected by electroporation into primary cultured MSCs isolated from rat bone marrow, with empty pcDNA3.1 expression plasmids (GenScript, Piscataway, NJ) transfection as control. Get A Quote

摘要

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exosome; functional recovery; miR-17–92 cluster; neural plasticity; neurogenesis; oligodendrogenesis; stroke
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