A computational model based on clinical data from pancreatic cancer patients has been successfully created and used for predicting tumor sizes in primary and metastasis sites and survival time from kinetics of tumor cells， such as growth rate， metastasis rate and mutation rate， etc. Whether this computational model could be fitted or necessary modification of some parameters for fitting in mice is unknown. Here， we developed a computational model in mice for spontaneous metastasis to simulate the process of tumor metastasis based on the mathematical frameworks.

Anti-cancer drug assessing，Clinical intervention strategies，Mathematical model，Overall survival time，Spontaneous metastasis m