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IL-1β-Mediated Up-Regulation of WT1D via miR-144-3p and Their Synergistic Effect with NF-κB/COX-2/HIF-1α Pathway on Cell Proliferation in LUAD.

Cell. Physiol. Biochem.. 2018; 
WuChen，LiXiaodong，ZhangDachuan，XuBin，HuWenwei，ZhengXiao，ZhuDanxia，ZhouQi，JiangJingting，WuChang
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Gene Synthesis WT1D gene was synthesized (purchased from Genscript, China) with restrictive digestion using Mlu I, subcloned into pLV-GFP plasmid and named pLV-GFP-WT1. Get A Quote

摘要

IL-1β is an important mediator of "inflammation-cancer" transformation through IL-1β/NF-κB/COX-2/HIF-1α signaling pathway， whereas certain portion of patients with lung adenocarcinoma (LUAD) still suffer from rapid tumor progression in clinical practice， indicating the occurrence of potential bypass.

关键词

IL-1β，LUAD，Proliferation，miR-14
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