Increased intestinal permeability with heightened translocation of Gramnegative bacteria， also known as "leaky gut"， is associated with the pathophysiology of neuroimmune disorders， such as Major Depressive Disorder (MDD)， Chronic Fatigue Syndrome (CSF) and (deficit) schizophrenia， as well as with general medical disorders， including irritable bowel syndrome. This review aims to summarize clinical biochemistry and molecular immunology tests that may aid in the recognition of leaky gut in clinical practice.
Increased intestinal permeability with heightened translocation of Gramnegative bacteria， also known as "leaky gut"， is associated with the pathophysiology of neuroimmune disorders， such as Major Depressive Disorder (MDD)， Chronic Fatigue Syndrome (CSF) and (deficit) schizophrenia， as well as with general medical disorders， including irritable bowel syndrome. This review aims to summarize clinical biochemistry and molecular immunology tests that may aid in the recognition of leaky gut in clinical practice.
