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The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.

Antioxid. Redox Signal.. 2017-12; 
MauneyChristopher H, RogersLeAnn C, HarrisReuben S, DanielLarry W, Devarie-BaezNelmi O, WuHanzhi, FurduiCristina M, PooleLeslie B, PerrinoFred W, HollisTh
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Gene Synthesis … cleavage site. Cysteine to alanine mutations (C320A, C341A, C350A, C522A, and C341-350A) were synthesized and sequenced by GenScript, using the pLM-SAMHD1 expression vector as a template. Expression constructs … Get A Quote

摘要

Proliferative signaling involves reversible posttranslational oxidation of proteins. However， relatively few molecular targets of these modifications have been identified. We investigate the role of protein oxidation in regulation of SAMHD1 catalysis.

关键词

Aicardi–Goutieres syndrome，HIV restriction，SAMHD1，enzyme catalysis，protein oxidation，redox sw
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