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PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.

J. Hepatol.. 2017-03; 
MukhopadhyayPartha, HorváthBéla, RajeshMohanraj, VargaZoltán V, GarianiKarim, RyuDongryeol, CaoZongxian, HolovacEileen, ParkOgyi, ZhouZhou, XuMing-Jiang, WangWei, GodlewskiGrzegorz, PalocziJanos, NemethBalazs Tamas, PersidskyYuri, LiaudetLucas, HaskóGyörgy, BaiPeter, BoularesA Hamid, AuwerxJohan, GaoBin, Pache
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Gene Synthesis … for 10 min, 45 cycles of 95 ℃ for 10s, 58 ℃ for 20s and 72 ℃ for 30s. To amplify the target genes, all primers were purchased from Genscript Biotechnology (Nanjing, China). Quantitative normalization of the cDNA in each sample was performed using … Get A Quote

摘要

Mitochondrial dysfunction， oxidative stress， inflammation， and metabolic reprograming are crucial contributors to hepatic injury and subsequent liver fibrosis. Poly(ADP-ribose) polymerases (PARP) and their interactions with sirtuins play an important role in regulating intermediary metabolism in this process. However， there is little research into whether PARP inhibition affects alcoholic and non-alcoholic steatohepatitis (ASH/NASH).

关键词

Alcohols，Fatty liver，Inflammation，Kupffer cells，Mitochondria，NAD(+)，NASH，Oxidative stress，Reactive oxygen spe
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