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Knockdown of SOX2OT inhibits the malignant biological behaviors of glioblastoma stem cells via up-regulating the expression of miR-194-5p and miR-122.

Mol. Cancer. 2017-11; 
SuRui, CaoShuo, MaJun, LiuYunhui, LiuXiaobai, ZhengJian, ChenJiajia, LiuLibo, CaiHeng, LiZhen, ZhaoLini, HeQianru, XueY
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Gene Synthesis … Full-length SOX3 or TDGF-1 gene were constructed in pIRES2-EGFP (GenScript, Piscataway, NJ, USA). MiR-194-5p agomir, miR-194-5p antagomir, miR-122 agomir, miR-122 antagomir and their respective negative control were synthesized (GenePharama, Shanghai, China) … Get A Quote

摘要

Accumulating evidence has highlighted the potential role of long non-coding RNAs (lncRNAs) in the biological behaviors of glioblastoma stem cells (GSCs). Here, we elucidated the function and possible molecular mechanisms of the effect of lncRNA-SOX2OT on the biological behaviors of GSCs.

关键词

Glioma,SOX2OT,SOX3,TDGF-1,miR-122,miR-19