The long noncoding RNA (lncRNA) MEG3 is involved in various biological processes including cell migration and cell proliferation. In present study， it was found that MEG3 and the intronic miR-770-5p were decreased in samples from HSCR patients. Besides， knockdown of MEG3 and miR-770-5p suppressed cell migration and proliferation， while cell cycle and apoptosis were not affected in human 293T and SH-SY5Y cells. SRGAP1 mRNA and protein upregulation was inversely correlated with miR-770-5p expression in tissue samples and cell lines， which was confirmed to be a target gene of miR-770-5p by dual-luciferase reporter assay. Moreover， silencing of SRGAP1 rescued the inhibition of cell migration and proliferation induced by MEG3 siRNA and miR-770-5p inhibition. The present study elucidates a novel mechanism of the development of HSCR and shows that the MEG3/miR-770-5p/SRGAP1 pathway plays a vital role in the pathogenesis of HSCR.