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MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells

Br. J. Cancer. 2017-10; 
ChenYing, WangDan-Dan, WuYe-Ping, SuDan, ZhouTian-Yi, GaiRen-Hua, FuYing-Ying, ZhengLin, HeQiao-Jun, ZhuHong, Ya
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Gene Synthesis … The pCMV-myc3-MDM2 plasmid was purchased from Addgene (plasmid #20935, Cambridge, MA, USA). And the deletion mutants were constructed by Genscript Co. Ltd (Shanghai, China). Human MDM2 siRNA was produced by GenePharma Co. Ltd (Shanghai, China) … Get A Quote

摘要

Metastasis accounts for the most lethal reason for the death of ovarian cancer patients， but remains largely untreated. Epithelial-mesenchymal transition (EMT) is critical for the conversion of early-stage ovarian tumours into metastatic malignancies. Thus the exploration of the signalling pathways promoting EMT would open potential opportunities for the treatment of metastatic ovarian cancer. Herein， the putative role of MDM2 in regulating EMT and metastasis of ovarian cancer SKOV3 cells was investigated.

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