2，3-butanediol (2，3-BD) is a bulk platform chemical with various potential applications such as aviation fuel. 2，3-BD has three optical isomers: (2R， 3R)-， (2S， 3S)- and meso-2，3-BD. Optically pure 2，3-BD is a crucial precursor for the chiral synthesis and it can also be used as anti-freeze agent due to its low freezing point. 2，3-BD has been produced in both native and non-native hosts. Several pathogenic bacteria were reported to produce 2，3-BD in mixture of its optical isomers including and . Engineered hosts based on episomal plasmid expression such as ， and are not ideal for industrial fermentation due to plasmid instability.
2，3-butanediol (2，3-BD) is a bulk platform chemical with various potential applications such as aviation fuel. 2，3-BD has three optical isomers: (2R， 3R)-， (2S， 3S)- and meso-2，3-BD. Optically pure 2，3-BD is a crucial precursor for the chiral synthesis and it can also be used as anti-freeze agent due to its low freezing point. 2，3-BD has been produced in both native and non-native hosts. Several pathogenic bacteria were reported to produce 2，3-BD in mixture of its optical isomers including and . Engineered hosts based on episomal plasmid expression such as ， and are not ideal for industrial fermentation due to plasmid instability.
