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TrkB/NTRK2, His, Human

Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor brain derived neurotrophic factor (BDNF). BDNF expression becomes restricted to subpopulations of taste receptor cells with specific functions,the receptor for BDNF, tropomyosin kinase B receptor (TrkB), may also become developmentally restricted to a subset of taste neurons and could be one factor that is differentially expressed across taste neuron subsets.
￥2500
Z05927-100

产品简介
Species Human
Protein Construction
TrkB/NTRK2 (Cys32-His430)_x000D_
Accession # AAH31835		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 45.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
TrkB/NTRK2, His, Human

Immobilized Human / Murine / Rat BDNF, No Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for TrkB/NTRK2, His, Human, His Tag with the EC50 of 0.11 μg/ml determined by ELISA. »

TrkB/NTRK2, His, Human

The purity of TrkB/NTRK2, His, Human is greater than 95% as determined by SEC-HPLC. »

TrkB/NTRK2, His, Human

TrkB/NTRK2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Neuron differentiation is likely regulated by a combination of transcription and growth factors. Embryonically, most geniculate neuron development is regulated by the growth factor brain derived neurotrophic factor (BDNF). BDNF expression becomes restricted to subpopulations of taste receptor cells with specific functions,the receptor for BDNF, tropomyosin kinase B receptor (TrkB), may also become developmentally restricted to a subset of taste neurons and could be one factor that is differentially expressed across taste neuron subsets.
Synonyms GP145-TrkB; NTRK2; TRKB
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.