| ￥2400 | |
| Z05913-100 | |
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| Species | Human | ||||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||||
| Expression System | HEK293 | ||||||
| Theoretical Molecular Weight | 17.2 kDa | ||||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 20-25 kDa based on Bis-Tris PAGE result. | ||||||
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). | ||||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Immobilized Human Trail, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for TRAIL R2/DR5/TNFRSF10B, His & Avi, Human, His Tag with the EC50 of 25.0ng/ml determined by ELISA. »
Immobilized TRAIL R2/DR5/TNFRSF10B, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-TRAIL R2 Antibody, hFc Tag with the EC50 of 3.3ng/ml determined by ELISA. »
The purity of TRAIL R2/DR5/TNFRSF10B, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »
TRAIL R2/DR5/TNFRSF10B, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Synonyms | CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
