| ￥3300 | |
| Z05720-100 | |
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| Species | Human | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 82.2 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 110-140 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Loaded Anti-OSMR Ab., hFc-Avi Tag on ProA-Biosensor can bind OSMR beta, His, Human, His Tag with an affinity constant of 2.48 nM as determined in BLI assay (Gator® Prime). »
Immobilized OSMR beta, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-OSMR Antibody, hFc Tag with the EC50 of 3.9ng/ml determined by ELISA. »
The purity of OSMR beta, His, Human is greater than 95% as determined by SEC-HPLC. »
OSMR beta, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
| Target Background | OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and promotes mitochondrial respiration. Deletion of OSMR impairs spare respiratory capacity, increases reactive oxygen species, and sensitizes BTSCs to IR-induced cell death. |
| Synonyms | IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ;IL-31R subunit β; IL-31R-β; OSMR β |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
