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LILRB2/CD85d/ILT4 hFc Chimera, Human

The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.
￥2200
Z05597-100

产品简介
Species Human
Protein Construction
LILRB2/CD85d/ILT4 (Gln22-His458)_x000D_
Accession # Q8N423-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 74.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
LILRB2/CD85d/ILT4 HFc Chimera, Human

Immobilized LILRB2/CD85d/ILT4 hFc Chimera, Human, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-LILRB2 Antibody, hFc-Avi Tag with the EC50 of 35.4ng/ml determined by ELISA. »

LILRB2/CD85d/ILT4 HFc Chimera, Human

Immobilized Biotinylated Human ANGPTL7, His Avi Tag at 5 μg/ml(100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for LILRB2/CD85d/ILT4 hFc Chimera, Human, hFc Tag with the EC50 of 3.09 μg/ml determined by ELISA. »

LILRB2/CD85d/ILT4 HFc Chimera, Human

The purity of LILRB2/CD85d/ILT4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

LILRB2/CD85d/ILT4 HFc Chimera, Human

LILRB2/CD85d/ILT4 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

LILRB2/CD85d/ILT4 HFc Chimera, Human

LILRB2/CD85d/ILT4 hFc Chimera, Human, hFc tag captured on Protein A Chip can bind Human HLA-G Tetramer, His Tag with an affinity constant of 9.20nM as determined in SPR assay (Biacore T200). »

LILRB2/CD85d/ILT4 HFc Chimera, Human

LILRB2/CD85d/ILT4 hFc Chimera, Human, hFc Tag captured on Protein A chip, can bind Human ANGPTL2, His Tag with an affinity constant of 0.14μM as determined in a SPR assay (Biacore T200). »

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技术背景
Target Background The immunoglobulin-like transcript (ILT) comprise a family of activating and inhibitory type immunoreceptors whose genes are located in the same locus that encodes killer cell Ig-like receptors (KIR). ILT4, also known as LIR-2 and LILRB2, is a type I transmembrane protein expressed primarily on monocytes and dendritic cells (DC). LILRB2 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles.
Synonyms CD85d; ILT4; ILT-4; ILT4CD85d; LILRB2; LIR2; MIR10
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.