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目录产品 » Fas/TNFRSF6/CD95 hFc Chimera, Human
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Fas/TNFRSF6/CD95 hFc Chimera, Human

CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations in this receptor are associated with a loss of apoptotic signaling and have been detected in an autoimmune disorder called autoimmune lymphoproliferative syndrome (ALPS) type Ia, which shares some clinical features with systemic lupus erythematosus (SLE).
￥2100
Z05272-100

产品简介
Species Human
Protein Construction
Fas/TNFRSF6/CD95 (Gln26-Asn173)
Accession # P25445-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 43.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
Fas/TNFRSF6/CD95 HFc Chimera, Human

Immobilized Fas/TNFRSF6/CD95 hFc Chimera, Human Ligand, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human Fas, hFc Tag with the EC50 of 58.1ng/ml determined by ELISA. »

Fas/TNFRSF6/CD95 HFc Chimera, Human

The purity of Fas/TNFRSF6/CD95 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

Fas/TNFRSF6/CD95 HFc Chimera, Human

Fas/TNFRSF6/CD95 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations in this receptor are associated with a loss of apoptotic signaling and have been detected in an autoimmune disorder called autoimmune lymphoproliferative syndrome (ALPS) type Ia, which shares some clinical features with systemic lupus erythematosus (SLE).
Synonyms FASLG receptor; CD95; APT1; FAS1; TNFRSF6; FAS; ALPS1A; APO1; FASTM; FasR
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.