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目录产品 » M-CSF R/CSF1R/CD115, His, Cynomolgus
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M-CSF R/CSF1R/CD115, His, Cynomolgus

CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
￥2600
Z04868-100

产品简介
Species Cynomolgus
Protein Construction
M-CSF R/CSF1R/CD115 (Ile99-Pro596)
Accession # G7P8P1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 56.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
M-CSF R/CSF1R/CD115, His, Cynomolgus

Immobilized M-CSF R/CSF1R/CD115, His, Cynomolgus, His Tag at 5 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 5.5ng/ml determined by ELISA. »

M-CSF R/CSF1R/CD115, His, Cynomolgus

The purity of M-CSF R/CSF1R/CD115, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

M-CSF R/CSF1R/CD115, His, Cynomolgus

M-CSF R/CSF1R/CD115, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

M-CSF R/CSF1R/CD115, His, Cynomolgus

M-CSF R/CSF1R/CD115, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus M-CSF, His Tag with an affinity constant of 0.889 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Synonyms CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.