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Cathepsin B, His, Human

Cathepsin B is an enzymatic protein that is a member of the peptidase (or protease) family. Elevated lev- els of cathepsin B occur in a wide variety of disease,causing numerous pathologies including cell death, inflammation, and the production of toxic peptides. For example, neuroscience research suggests that cathepsin B plays a role in inducing epilepsy resulting in a significant amount of cell death. Seizure-induced rats treated with a cathepsin B inhibitor exhibited improved neurological scores and learning ability with reduced neuronal cell death.
￥1160
Z03322

产品简介
Species Human
Protein Construction
Cathepsin B (Arg18-Ile339)
Accession # P07858		 Poly-His
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Expression System CHO
Apparent Molecular Weight ~43 kDa, on SDS-PAGE under reducing conditions.
Formulation Supplied as a 0.2 μm filtered solution in 25 mM Tris, 150 mM NaCl, 20% Glycerol, pH 8.0.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below and 1-2 weeks at 4°C. For long term storage, aliquot and store at -70°C or below. Avoid repeated freeze-thaw cycles.
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图例
Cathepsin B, His, Human

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Cathepsin B, His, Human

Lane 1: 2 μg of Cathepsin B, His, Human, reducing (R)
> 95% as analyzed by SDS-PAGE »

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技术背景
Target Background Cathepsin B is an enzymatic protein that is a member of the peptidase (or protease) family. Elevated lev- els of cathepsin B occur in a wide variety of disease,causing numerous pathologies including cell death, inflammation, and the production of toxic peptides. For example, neuroscience research suggests that cathepsin B plays a role in inducing epilepsy resulting in a significant amount of cell death. Seizure-induced rats treated with a cathepsin B inhibitor exhibited improved neurological scores and learning ability with reduced neuronal cell death.
Synonyms Cathepsin B; APP secretase; APPS
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.